Glutamine Test

₹ 1599

₹ 2799

SAVE 42%

Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of glutamine-deprived cells. However, pancreatic cancers are often poorly vascularized and limited in glutamine supply, in alignment with recent concerns on the significance of glutaminolysis in pancreatic cancer. Here, we show that aKG-mediated rescue of glutamine-deprived pancreatic ductal carcinoma (PDAC) cells requires glutamate ammonia ligase (GLUL), the enzyme responsible for de novo glutamine synthesis. GLUL-deficient PDAC cells are capable of the TCA cycle but defective in aKG-coupled glutamine biosynthesis and subsequent nitrogen anabolic processes. Importantly, GLUL expression is elevated in pancreatic cancer patient samples and in mouse PDAC models. GLUL ablation suppresses the development of KrasG12D-driven murine PDAC. Therefore, GLUL-mediated glutamine biosynthesis couples the TCA cycle with nitrogen anabolism and plays a critical role in PDAC.

42% off

Useful for Patients

Early Detection of Cancer

Detection of Cancer Relapse

Monitoring of cancer therapy.

Test Details

Sample Type

Analysis of CTC Markers

Cancer type

All types of Cancers

Final results

7–10 days

Sample Size

7–10 ml peripheral whole blood


Oncodiscover Tests

Every Cancer is Unique
But all cancers have one thing in common

“Circulating Tumour Cells”

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